Cellular Signaling through Multifunctional Ca2+/Calmodulin-dependent Protein Kinase II
نویسندگان
چکیده
منابع مشابه
Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II.
The balance between excitatory and inhibitory synapses is crucial for normal brain function. Wnt proteins stimulate synapse formation by increasing synaptic assembly. However, it is unclear whether Wnt signaling differentially regulates the formation of excitatory and inhibitory synapses. Here, we demonstrate that Wnt7a preferentially stimulates excitatory synapse formation and function. In hip...
متن کاملSignaling through protein kinase C.
Protein kinase C (PKC) comprises a large family of serine/threonine kinases which are activated by many extracellular signals. Inside the cell, PKCs are regulated by a variety of lipid second messengers, including the ubiquitous diacylglycerol and phosphatidylserine. Phosphorylation has also emerged as an important mechanism of regulation of all PKCs. Work in the last 20 years has provided evid...
متن کاملThe multifunctional Ca /calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9
Jason A. Scott, Litao Xie, Hui Li, Weiwei Li, Julie B. He, Philip N. Sanders, A. Brent Carter, Johannes Backs, Mark E. Anderson, and Isabella M. Grumbach Departments of Medicine, Molecular Physiology and Biophysics, Free Radical and Radiation Biology Program, Radiation Oncology, Carver College of Medicine, University of Iowa; Iowa City VA Medical Center, Iowa City, Iowa; and Department of Inter...
متن کاملThe multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9.
The multifunctional CaMKII has been implicated in vascular smooth muscle cell (VSMC) migration, but little is known regarding its downstream targets that mediate migration. Here, we examined whether CaMKII regulates migration through modulation of matrix metalloproteinase 9 (MMP9). Using CaMKIIδ(-/-) mice as a model system, we evaluated migration and MMP9 regulation in vitro and in vivo. After ...
متن کاملStructural examination of autoregulation of multifunctional calcium/calmodulin-dependent protein kinase II.
Regulation of Ca(2+)/calmodulin-dependent protein kinase II is likely based on an auto-inhibitory mechanism in which a segment of the kinase occupies the catalytic site in the absence of calmodulin. We analyze potential auto-inhibitory associations by employing charge reversal and hydrophobic-to-charged residue mutagenesis. We identify interacting amino acid pairs by using double mutants to tes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.r000013200